G Protein Coupled Receptors

Structure

Gebonden Engels 2013 9780123918611
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This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain.

Specificaties

ISBN13:9780123918611
Taal:Engels
Bindwijze:Gebonden

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Inhoudsopgave

<ol> <ol> <li>G Protein Coupled Receptors: Techniques for Probing Structure<br></li> <li>Comformational Ensemble View of G Protein-Coupled Receptors and The Effect of Mutations and Ligand Binding</li> <li>Structural Evolution of G-Protein-Coupled Receptors: A Sequence Space Approach</li> <li>Directed Evolution of G Protein-Coupled Receptors for High Functional Expression and Detergent Stability</li> <li>The Role of Hydrophobic Amino Acids in the Structure and Function of the Rhodopsin Family of G Protein-Coupled Receptors</li> <li>Structure of β-Adrenergic Receptors</li> <li>Advances in Methods to Characterize Ligand-Induced Ionic Lock and Rotamer Toggle Molecular Switch in G-Protein Coupled Receptors</li> <li>Crystallogenesis of Adenosine A<SUB>2A</SUB> Receptor – T4 Lysozyme Fusion Protein: A Practical Route for the Structure</li> <li>Probing GPCR Structure: Adenosine and P2Y Nucleotide Receptors</li> <li>Strategies for Studying the Ligand Binding Site of GPCRs: Photoaffinity Labeling of the VPAC1 Receptor, a Prototype of Class B GPCRs</li> <li>Expression of Mammalian G Protein-Coupled Receptors in Caenorhabditis Elegans</li> <li>Expression, Purification and Structural Analysis of Intracellular C-Termini from Metabotropic Glutamate Receptors</li> <li>Unnatural Amino Acid Mutagenesis of GPCRs Using Amber Codon Suppression and Bioorthogonal Labeling</li> <li>Mapping a Ligand Binding Site Using Genetically-Encoded Photoactivatable Crosslinkers</li> <li>Alternative mRNA Splicing of G Protein-Coulped Receptors</li> <li>Functional Residues of the CB1 Cannabinoid Receptor</li> </ol> <p> </p></ol>

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€ 194,75
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        G Protein Coupled Receptors