A Roadmap to Nonhematopoietic Stem Cell-Based Therapeutics

From the Bench to the Clinic

Paperback Engels 2018 9780128119204
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Samenvatting

A Roadmap to Non-hematopoietic Stem Cell-Based Therapeutics: From the Bench to the Clinic is a resource that provides an overview of the principles of stem cell therapy, the promises and challenges of using stem cells for treating various clinical conditions, and future perspectives. The overall goal is to facilitate the translation of basic research on stem cells to clinical applications. The properties of stem cells from various sources are reviewed and the advantages and disadvantages of each for clinical use are discussed. Modifying stem cell properties through preconditioning strategies using physical, chemical, genetic, and molecular manipulation to improve cell survival, increase cell differentiation potential, enhance production of paracrine factors, and facilitate homing to the site of injury or disease upon transplantation are reviewed. Various routes of stem cell administration and dosing, and the duration of effects, are explored. Individual chapters are written by experts in the field and focus on the use of stem cells in treating various degenerative diseases, autoimmune diseases, wound healing, cardiovascular disease, spinal cord injury, oral and dental diseases, and skeletal disorders. Finally, experts in the regulatory arena discuss mechanisms used in different countries for approving the use of stem cells to treat diseases and many common issues that are typically encountered while seeking approval for this class of therapeutic agent.

Specificaties

ISBN13:9780128119204
Taal:Engels
Bindwijze:Paperback

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Inhoudsopgave

<p>Part 1 Principles and Concepts</p> <p>1. What Can We Learn From This Book?</p> <p>Travis J. Block, David D. Dean and Xiao-Dong Chen</p> <p>2. Features of Mesenchymal Stem Cells</p> <p>Stan Gronthos</p> <p>3. Maintenance and Culture of  MSCs</p> <p>Milos Marinkovic, David D. Dean and Xiao-Dong Chen</p> <p>4. Manufacturing Mesenchymal Stromal Cell Banks</p> <p>Jamie Hoover and Patrick J. Hanley</p> <p>Part 2 Promises and Challenges of MSC-Based Therapies</p> <p>5. Mesenchymal Stem Cell-Based Therapy of Osteoarthritis: Current Clinical Developments and Future Therapeutic Strategies</p> <p>Maxime Ruiz, Marie Maumus, Christian Jorgensen and Daniele Noel</p> <p>6. Mesenchymal Stem Cell Therapy in Graft Versus Host Disease</p> <p>Shivaprasad Manjappa, Rizwan Romee and Armin Rashidi</p> <p>7. Systemic Lupus Erythematosus</p> <p>Dandan Wang and Lingyun Sun</p> <p>8. Mesenchymal Stem Cell-Based Therapies for Repair and Regeneration of Skin Wounds</p> <p>Shanmugasundaram Natesan, Randolph Stone, Rodney K. Chan and Robert J. Christy</p> <p>9. Myocardial Infarction</p> <p>Natalia Rozwadowska and Maciej Kurpisz</p> <p>10. Bone Marrow Mesenchymal Stem Cells as a New Therapeutic Approach for Diabetes Mellitus</p> <p>Joseph Kim, John Z. Q. Luo and Luguang Luo</p> <p>11. Mesenchymal Stem Cell-Based Therapy for Chronic Kidney Disease</p> <p>Maria V. Irazabal, LaTonya J. Hickson and Alfonso Eirin</p> <p>12. Promises and Challenges of MSC-Based Therapies: Parkinson Disease and Parkinsonism</p> <p>Ashley Aaroe and Claire Henchcliffe</p> <p>13. Spinal Cord Injury</p> <p>K. A. Ruppert, S. D. Olson and C. S. Cox</p> <p>14. Stem Cell-Based Restoration of Salivary Gland Function</p> <p>Olivia N. Tran, Hanzhou Wang, David D. Dean, Xiao-Dong Chen and Chih-Ko Yeh</p> <p>15. Tooth and Dental Pulp Regeneration</p> <p>Bei Li, Chen Xi and Yan Jin</p> <p>Part 3: Future Perspectives </p> <p>16. MSCs as Biological Drugs</p> <p>Thekkeparambil Chandrabose Srijaya, Sandhya Sriram, Noor Hayaty Abu Kasim and Shigeki Sugii</p> <p>17. Mesenchymal Stem Cell-Derived Products for Tissue Repair and Regeneration</p> <p>Anand Srinivasan, Michelle Lynn Fults, Peter Supronowicz, Roberto Esquivel and Rogelio Zamilpa</p> <p>18. Use of MSCs in Antiaging Strategies</p> <p>Travis J. Block, David D. Dean and Xiao-Dong Chen</p> <p>19. Regulatory Developments for Nonhematopoietic Stem Cell Therapeutics: Perspectives From the EU, the USA, Japan, China, India, Argentina, and Brazil</p> <p>Achim Rosemann, Gabriela Bortz and Federico Vasen</p>

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        A Roadmap to Nonhematopoietic Stem Cell-Based Therapeutics