Epigenetics in Cardiovascular Disease

<p>SECTION I INTRODUCTORY INFORMATION<br>1. The ever-growing burden of cardiovascular disease<br>2. Epigenetics concepts: An overview<br>3. From classical signaling pathways to the nucleus</p> <p>SECTION II EPIGENETICS MECHANISMS IN CARDIOVASCULAR DISEASE<br>4. DNA methylation in heart failure<br>5. Histone modifications in cardiovascular disease initiation and progression<br>6. RNA modifications in cardiovascular disease—An experimental and computational perspective<br>7. Regulatory RNAs in cardiovascular disease<br>8. Regulation of splicing in cardiovascular disease<br>9. Cardiac transcriptomic remodeling in metabolic syndrome<br>10. Sex differences in epigenetics mechanisms of cardiovascular disease<br>11. Epigenetics in cardiac development and human induced pluripotent stem cells</p> <p>SECTION III BIOMARKER VALUE<br>12. Peripheral blood DNA and RNA biomarkers of cardiovascular disease in clinical practice<br>13. Epigenetics and physical exercise<br>14. Long noncoding RNAs and circular RNAs as heart failure biomarkers<br>15. Artificial intelligence in clinical decision-making for diagnosis of cardiovascular disease using epigenetics mechanisms</p> <p>SECTION IV THERAPEUTIC POTENTIAL<br>16. Therapeutic strategies for modulating epigenetic mechanisms in cardiovascular disease</p> <p>SECTION V METHODOLOGICAL ISSUES<br>17. Single-cell RNA sequencing in cardiovascular science<br>18. Good laboratory and experimental practices for microRNA analysis in cardiovascular research<br>19. Analytical challenges in microRNA biomarker development: Best practices for analyzing microRNAs in cell-free biofluids<br>20. Concept of biological reference materials for RNA analysis in cardiovascular disease<br>21. Unbiased bioinformatics analysis of microRNA transcriptomics datasets and network theoretic target prediction</p>