David E. Fisher
Tumor Suppressor Genes in Human Cancer
Gebonden Engels 2000 2001e druk 9780896038073Levertijd ongeveer 9 werkdagen
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Samenvatting
David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.
Specificaties
ISBN13:9780896038073
Taal:Engels
Bindwijze:gebonden
Aantal pagina's:386
Uitgever:Humana Press
Druk:2001
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Inhoudsopgave
1 Animal Models for Tumor Suppressor Genes.- 2 Viral Oncoproteins as Probes for Tumor Suppressor Function.- 3 Tumor Suppressors in Metastasis.- 4 Apoptosis: Machinery of Cell Death in Development and Cancer.- 5 Drug Discovery in Oncology.- 6 Retinoblastoma Protein in Growth Control and Differentiation.- 7 p53 Tumor Suppressor Protein.- 8 p16 Tumor Suppressor.- 9 DNA Mismatch Repair in Tumor Suppression.- 10 PTEN: Regulator of Phosphoinositide 3-Kinase Signal Transduction.- 11 Neurofibromatoses.- 12 Von Hippel-Lindau Disease: Clinical and Molecular Aspects.- 13 Wilms’ Tumor: A Developmental Anomaly.- 14 Fanconi Anemia Pathway and Cancer Susceptibility.
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