Chemical Protein Synthesis

Sulfated Glycoprotein Synthesis.-&nbsp;Total Chemical Synthesis of a SARS-CoV-2 Miniprotein Inhibitor LCB1.-&nbsp;Serine/Threonine Ligation and Cysteine/Penicillamine Ligation.-&nbsp;Continuous-flow synthesis of N-Methylated Peptides via Generation of an Acyl N-Methylimidazolium Cation.-&nbsp;Covalent Reactive Peptides to Block Protein – Protein Interactions and Inhibit Microbe-Host Interaction.-&nbsp;Ynamide-Mediated Synthetic Approach to Thioamide Substituted Peptides.-&nbsp;Improved Handling of Peptide Segments Using Side Chain-Based “Helping Hand” Solubilizing Tools.-&nbsp;Helical Stabilization of Peptide&nbsp;Macrocycles&nbsp;by Stapled Architectures.-&nbsp;General solution to the preparation of ꞵ-thiolated/Selenolated Amino Acids Via Visible Light Catalyzed Asymmetric Giese reaction.-&nbsp;Side-chain Anchoring Strategies for the Synthesis of Peptide Thioesters and Selenoesters.-&nbsp;Preparation of Site-Specific Succinylated Histone Mimics to Investigate ItsImpact On Nucleosome Dynamics.-&nbsp;Protein Synthesis Via Activated Cysteine-Directed Protein Ligation.-&nbsp;Sulfonium Tethered Peptide.-&nbsp;PAL-mediated Ligation for Protein and Cell-Surface Modification.-&nbsp;Development of a Glycoform Library-based Strategy to Decipher the Role of Protein Glycosylation.- A&nbsp;Selenium-Based Cysteine Surrogate for Protein Chemical Synthesis.-&nbsp;Removable Backbone Modification (RBM) Strategy for the Chemical Synthesis of Hydrophobic Peptides/Proteins.&nbsp;<p><br></p>