Purine Metabolism in Man—II

of Volume 76 A.- History of Gout. Including Comments from an Illustrious Timeless Gathering.- Metabolic Pathways of Purines.- A Multienzyme Complex for De Novo Purine Biosynthesis.- Coordinate Regulation of the Proximal and Distal Steps of the Pathway of Purine Synthesis De Novo in WI-L2 Human Lymphoblasts.- Purine Toxicity in Human Lymphoblasts.- Studies on the Regulation of the Biosynthesis of Myocardial Adenine Nucleotides.- Effect of Triiodothyronine on the Biosynthesis of Adenine Nucleotides and Proteins in the Rat Heart.- Altered Synthesis and Catabolism of Purine Nucleotides in Regulatory Mutants of Saccharomyces Cerevisiae.- Phosphoribosylpyrophosphate Synthesis in Human Erythrocytes: Inhibition by Purine Nucleosides.- Human Phosphoribosylpyrophosphate Synthetase: Relation of Activity and Quaternary Structure.- Transfer of Resistance to Selective Conditions from Fibroblasts with Mutant Feedback-Resistant Phosphoribosylpyrophosphate Synthetase to Normal Cells. A Form of Metabolic Cooperation.- Phosphoribosylpyrophosphate Degradation in Human Tissues.- Properties of the Phosphoribosylpyrophosphate-Glutamine Amidotransferase of the Human Leucemic Cells.- A Purine Auxotroph Deficient in Phosphoribosylpyrophosphate Amidotransferase and Phosphoribosylpyrophosphate Aminotransferase Activities with normal Activity of Ribose-5-phosphate Aminotransferase.- Biochemical Studies of Purine Auxotrophs of Drosophila Melanogaster.- Inosine Triphosphate Metabolism in Human Erythrocytes.- Oxypurine and 6-Thiopurine Nucleoside Triphosphate Formation in Human Erythrocytes.- Activity of Salvage Pathway in Erythrocytes of Newborn Infants, Children, and Adults.- Purine Phosphoribosyltransferase in Human Erythrocyte Ghosts.- The Localisation of the Purine Phosphoribosyl-transferase in Rat Liver Organelles.- Reversible and Irreversible Inhibition of Hypoxanthine Phosphoribosyl-transferase.- Purification and Characterization of Hypoxanthine-Guanine Phosphoribosyltransferase from Cultured HTC Cells.- Evidence for the Existence of Different Types of Metabolic Cooperation.- Stability of the Azaguanine Resistant Phenotype in Vivo.- Functioning of Purine Salvage Pathways in Escherichia Coli K-12.- Metabolism of Intravenous Adenine in the Pig.- Pattern of Purine-Nucleotide Metabolism in Hepatopancreas of Helix Pomatia (Gastropoda).- Isozymes of AMP Deaminase.- Purification of Human Erythrocyte Adenosine Deaminase.- Adenosine Deaminase: Characterization of the Molecular Heterogeneity of the Enzyme in Human Tissue.- Human 5?-Nucleotidase : Multiple Molecular Forms and Regulation.- Subcellular Distribution of Purine Degrading Enzymes in the Liver of the Carp (Cyprinus Carpio L.).- Mutations Affecting Purine Metabolism in Man.- Purine Enzyme Abnormalities: A Four Year Experience.- Fibroblast Phosphoribosylpyrophosphate and Ribose-5-phosphate Concentration and Generation in Gout with Purine Overproduction.- Familial Distribution of Increased Erythrocyte Phosphoribosylpyrophosphate Levels.- X-linked Pattern of Inheritance of Gout due to Mutant Feedback-Resistant Phosphoribosylpyrophosphate Synthetase.- Incidence of APRT Deficiency.- Complete Deficiency of Adenine Phosphoribosyl-transferase: Report of a Family.- Purine Synthesis and Excretion in Mutants of the W1-L2 Human Lymphoblastoid Line Deficient in Adenosine Kinase (AK) and Adenine Phosphoribosyl-transferase (APRT).- Partial HPRT Deficiency: Heterozygotes Exhibit One Cell Population in Intact Cell Assays.- Diminished Affinity for Purine Substrates as a Basis for Gout with Mild Deficiency of Hypoxanthine-Guanine Phosphoribosyl-transferase.- Purine and Pyrimidine Nucleotide Concentrations in Cells with Decreased Hypoxanthine-Guanine Phosphoribosyltransferase (HGPRT) Activity.- Electrophoretic Variation in Partial Deficiencies of Hypoxanthine-Guanine Phosphoribosyltransferase.- Xanthine Oxidase Activity in a Gouty Patient with Partial Deficiency of HGPRT.- Experience with Detection of Heterozygous Carriers and Prenatal Diagnosis of Lesch-Nyhan Disease.- HGPRT-Positive and HGPRT-Negative Erythrocytes in Heterozygotes for HGPRT Deficiency.- Study of Immunoreactive Material in Patients with Deficient HPRT Activity.- Effects of Inosine on Purine Synthesis in Normal and HGPRT-Deficient Human Fibroblasts.- An Alternate Metabolic Route for the Synthesis of Inosine-5?-phosphate (IMP) in the Lesch-Nyhan Erythrocyte.- Adenosine Metabolism in Permanent Lymphocyte Lines and in Erythrocytes of Patients with the Lesch-Nyhan Syndrome.- Purine-Nucleoside Phosphorylase and Adenosine Aminohydrolase Activities in Fibroblasts with the Lesch-Nyhan Mutation.- Altered Excretion of 5-Hydroxyindoleacetic Acid and Glycine in Patients with the Lesch-Nyhan Disease.- Xanthinuria, Lithiasis and Gout in the Same Family.- Immunological Aspects.- Immunological Aspects of Purine Metabolism.- Phosphoribosylpyrophosphate Amidotransferase Activity in Unstimulated and Stimulated Human Lymphocytes.- Adenosine and Guanosine Metabolism During Phytohemagglutinin Induced Transformation of Human Lymphocytes.- Adenine and Adenosine Metabolism in Phytohemagglutinin-Stimulated and Unstimulated Normal Human Lymphocytes.- Adenine and Adenosine Metabolism in Lymphocytes Deficient in Adenosine Deaminase Activity.- Immunoreactive Adenosine Deaminase in Cultured Fibroblasts from Patients with Combined Immunodeficiency Disease.- Urinary Purines in a Patient with a Severely Defective T Cell Immunity and a Purine Nucleoside Phosphorylase Deficiency.- A Second Case of Inosine Phosphorylase Deficiency with Severe T-Cell Abnormalities.- Relationship Between Carbohydrate, Lipid and Purine Metabolism.- Regulation of De Novo Purine Synthesis in Human and Rat Tissue: Role of Oxidative Pentose Phosphate Pathway Activity and of Ribose-5-phosphate and Phosphoribosylpyrophosphate Availability.- Hepatic Gluconeogenesis and Urate Formation from Various Nucleosides.- Influence of Carbohydrates on Uric Acid Synthesis in the Isolated Perfused Chicken Liver.- Studies on the Influence of Ethanol and of Lactic Acid on Uric Acid Metabolism.- Carbohydrate Induced Increase in Uric Acid Synthesis. Studies in Human Volunteers and in Laboratory Rats.- Pharmacologically Induced Erythrocyte Phosphoribosylpyrophosphate Variations.- Isolated Rat Liver Cells — Purine Metabolism and Effects of Fructose.- Studies on the Effects of Fructose and Xylitol in the Rat Liver: 5?-Nucleotidase, Adenosine Deaminase, De Novo Purine Synthesis.- The NADP/NADPH2 Ratio in Erythrocytes of Hyperuricemic Patients, a Possible Regulator Between Purine, Carbohydrate and Lipid Metabolism.- Hypertriglyceridaemia and Chenodeoxycholic Acid.- Fatty Acid Composition of Plasma Lipid Fractions in Gout.- Methodology.- An Improved Method for the Electrophoretic Separation and Histochemical Identification of 5-Phosphoribosyl-1-pyrophosphate Synthetase Using Microgram Quantities of Crude Cell Extracts.- A New Assay for the Determination of Phosphoribosylamine.- Facilitated Purification of Hypoxanthine Phosphoribosyltransferase by Affinity Chromatography.- Ultramicrochemistry: A Contribution to the Analysis of Purine Metabolism in Man.- Ultramicrochemical Studies on Enzyme Kinetics.- Localization of Xanthine Oxidase Activity in Hepatic Tissue. A New Histochemical Method.- Analysis of Purines and their Nucleosides by the Reverse Phase Partition Mode of High Pressure Liquid Chromatography.- Enzymatic Determination of Urate, Cholesterol and Triglycerides in the Synovial Fluid with the Centrifugal Fast Analyzer.- Author Index.