Disruption of Protein-Protein Interfaces

In Search of New Inhibitors

Gebonden Engels 2013 2013e druk 9783642379987
€ 120,99
Levertijd ongeveer 9 werkdagen
Gratis verzonden

Samenvatting

"Disruption of Protein-Protein Interfaces" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces. The authors detail experimental and computational tools to tackle the subject and highlight the contribution of the Italian research community to the field. Evidence shows that blocking or modulating protein-protein interactions might lead to the development of useful new drugs. Consequently, in recent years great effort has been dedicated to unveiling the molecular details of protein-protein interfaces by structural techniques e.g. X-ray diffraction, NMR spectroscopy. This book, written and edited by leaders in the field, provides examples from the literature of successes and failures to develop drug-like molecules effective in interacting at protein-protein interfaces.

Specificaties

ISBN13:9783642379987
Taal:Engels
Bindwijze:gebonden
Aantal pagina's:161
Uitgever:Springer Berlin Heidelberg
Druk:2013

Lezersrecensies

Wees de eerste die een lezersrecensie schrijft!

Inhoudsopgave

Drug discovery by targeting protein-protein interactions.- Protein-Protein Interaction Inhibitors: case studies on small molecules and natural compounds.- Disrupting Protein-Protein Interfaces using GRID Molecular Interaction Fields.- NMR as a tool to target protein-protein interactions.- Protein-protein interactions in the solid state The troubles of crystallizing of protein- protein complexes.- Fluorescence observables and enzyme kinetics in the investigation of PPI modulation by small molecules Detection, mechanistic insight, functional consequences.

Managementboek Top 100

€ 120,99
Levertijd ongeveer 9 werkdagen
Gratis verzonden

Rubrieken

    Personen

      Trefwoorden

        Disruption of Protein-Protein Interfaces