Biocombinatorial Approaches for Drug Finding

Protein Domain Fold Similarity and Natural Product Structure as Guiding Principles for Compound Library Design.- Sources of Polyketides and Non-Ribosomal Peptides.- Polyketide Synthases: Mechanisms and Models.- Functional and Structural Basis for Targeted Modification of Non-Ribosomal Peptlde Synthetases.- Prerequisites for Combinatorial Biosynthesis: Evolution of Hybrid NRPS/PKS Gene Clusters.- Engineering Glycosylation in Bioactive Compounds by Combinatorial Biosynthesis.- Glycosyltransferases and Other Tailoring Enzymes as Tools for the Generation of Novel Compounds.- Enzymatic Incorporation of Halogen Atoms into Natural Compounds.- From Glucose to Antibiotics: What Controls the Fluxes?.- Precursor-Directed Biosynthesis for the Generation of Novel Glycopetides.- Tool-Box: Tailoring Enzymes for Bio-Combinatorial Lead Development and as Markers for Genome-Based Natural Product Lead Discovery.- Natural Product Biosynthetic Assembly Lines: Prospects and Challenges for Reprogramming.