Chromosomes Today

Prologue: Cytogenetics: yesterday, today and forever;a conceptual and historical view. Part One: Sequence organisation in chromosomes: Chromosome differentiation using nucleuses: an overview. Y-linked genes and spermatogenesis in primates. Subchromosomal painting libraries (SCPLs) from somatic cell hybrids. The relationship between gene density and chromosome banding patterns in mammalian nuclei. Part Two: Maintanence and breakdown of stability. Genes controlling chromosome structure in Drosophilia melanogaster. Retrotransposons at Drosophilia telomeres and terminal chromosome dificiencies. Interspecific micronucleus model for the study of induced chromosome abberations in human male germ cells. Characterization of amplified DNA sequences in human cancers. Part Three: Control mechanisms. Transciption factories and chromosome structure. The replication of ribosomal RNA genes in eukaryotes. Genomic interactions; gene expression, DNA methylation and nuclear architecture. Gametic imprinting at the mouse and the human IGF2R/MPR300 locus. Part Four: Meiotic mobility and recombination: Chromosome behavior in earliest meiotic prophase. Univalent orentation in living meiocytes. Proteins controlling sister-chromatid cohesion. Expanding genetic maps: reevaluation of the relationship between chiasmatic and crossovers. Part Five: Evolutionary dynamics: Evolution of a near-neutral B chromosome. Chromosome painting in wheat. New insights into chromosome evolution in plants from molecular cytogenetics. A saltation model of karyotypic evolution in the Octodontoidea (Mammalia, Rodentia). Epilogue: The who is who of chromosomes.