The addition of chemotherapy as an effective means to treat cancer has had a major impact on selected human malignancies. Due to a general inability to dif­ ferentiate between normal and neoplastic cells, little selectivity exists in currently used oncolytic drugs.  Meer

Biochemical Modulation at the present time defines an area of study in which the intracellular metabolism of a given anti­ cancer agent is modulated (usually by a noncytotoxic agent or a cytotoxic agent at sufficiently low dosage to make it non­ cytotoxic) in order to either increase the effectiveness of the particular agent against tumor cells or decrease its cytotox­ icity against normal cells.  Meer

Neoplastic disease confined to the liver is an important worldwide problem. In the industrialized nations, metastatic disease of the most common cancers involves the liver in upwards of 50% of cases.  Meer

This book presents in a comprehensive way cur­ the clinical care of the patient with head and neck rent advances in the management of neoplasia cancer involvement and/or its complications.  Meer

The field of pediatric oncology encompasses four groups of malignancies - acute leukemias, brain tumors, lymphomas and solid tumors. 1'he history, diagnosis and management of children with acute leukemias and lymphomas has been thoroughly examined in several excellent textbooks of pediatric hematology and oncology.  Meer

KENNETH A. FOON and ALTON C. MORGAN, JR. Passive immunotherapy using heteroantisera for the treatment of cancer in animals and humans has been studied for over 50 years.  Meer

The past twenty years have witnessed significant advances in the treatment of cancer by surgery and radiation therapy. Gains with cytotoxic chemotherapy have been much more modest.  Meer

The methodology of drug development has been the subject of extensive dis­ cussion by a relatively small group of individuals in industry and government who have been intimately concerned with the identification and study of new anticancer drugs.  Meer

The chapters in this book are those presented at the Second International Symposium on Fundamental Problems in Breast Cancer held at Banff, Alberta, April 26-29, 1986.  Meer

Proceedings of the Fifth International Symposium, held in Abano Terme (Padova), italy, June 29-July 2, 1987  Meer

A multidisciplinary approach to the problems related to the diagnosis, treat­ ment, and rehabilitation of patients with oral cancer and precancer is reflected in the various specialties of the authors who contributed to this book.  Meer

Over the past 30 years many significant advances have been made in the management of a number of disseminated malignant diseases. The prognosis for diseases such as childhood leukaemia, choriocarcinoma and Hodgkin's disease has gradually been transformed as better anti tumour agents have become available and their clinical use has been refined.  Meer

In recent years much progress has been made in knowledge and understanding of the biology of cutaneous melanoma. In this respect etiological factors, prognostic factors, antigen expression of melanoma cells, immune response and mechanisms of metastasis formation have to be mentioned.  Meer

The use of intra-arterial therapy is not nearly as easy as the use of systemic intravenous therapy. The unique complications of intra-arterial therapy can be minimized by selecting the right drug delivery system and by judicious use of appropriate chemotherapeutic agents.  Meer

Breast cancer, being a disease with very high prevalence in the female population, has permanently attracted the attention of biologists, biochemists, pathologists, surgeons, and oncologists.  Meer

There have been significant advances in the treatment of sarcomas in the past several years. Further, different clini­ cal treatment programs are being advocated in different areas including surgery alone, surgery with preoperative or post­ operative chemotherapy, surgery with different radiotherapy modalities, with each investigator espousing his own treat­ ment program.  Meer

The success rate for treatment of primary neoplasms has improved sig­ nificantly due to improved surgical, radiotherapy, and chemotherapy methods, and by supportive patient care.  Meer