Central Nervous System Diseases

1 • The Cholinergic Hypothesis a Generation Later: Perspectives Gained on the Use and Integration of Animal Models.- 2 • Patterns of Cognitive Decline in the Aged Rhesus Monkey.- 3 • Cholinergic Lesions as a Model of Alzheimer’s Disease: Effects of Nerve Growth Factor.- 4 • The Immunolesioned Animal as a Model of Transmitter Dysfunction.- 5 • An Intracerebral Tumor Necrosis Factor-? Infusion Model for Inflammation in Alzheimer’s Disease.- 6 • The Senescence-Accelerated Mouse as a Possible Animal Model of Senile Dementia.- 7 • Transgenic Mice Overexpressing Presenilin cDNAs: Phenotype and Utility in the Modeling of Alzheimer’s Disease.- 8 • Intervention Strategies for Degeneration of Dopamine Neurons in Parkinsonism: Optimizing Behavioral Assessment of Outcome.- 9 • Development of Behavioral Outcome Measures for Preclinical Parkinson’s Research.- 10 • Behavioral Assessment in the Unilateral Dopamine-Depleted Marmoset.- 11 • Molecules for Neuroprotection and Regeneration in Animal Models of Parkinson’s Disease.- 12 • Antisense Knockdown of Dopamine Receptors.- 13 • Is Trophic Factor Gene Disruption a “Knockout” Model for Parkinson’s Disease?.- 14 • Operant Analysis of Striatal Dysfunction.- 15 • Intrastriatal Injections of Quinolinic Acid as a Model for Developing Neuroprotective Strategies in Huntington’s Disease.- 16 • Systemic Administration of 3-Nitropropionic Acid: A New Model of Huntington’s Disease in Rat.- 17 • Replicating Huntington Disease’s Phenotype in Nonhuman Primates.- 18 • Transgenic Mouse Models of Huntington’s Disease.- 19 • Rigid Indentation Models of Traumatic Brain Injury in the Rat.- 20 • Rodent Ischemia Models of Embolism and Ligation of the Middle Cerebral Artery: Clinical Relevanceto Treatment Strategies of Stroke.- 21 • A Primate Model of Hypertensive Cerebrovascular Disease.- 22 • Nictotinic Therapeutics for Tourette Syndrome and Other Neuropsychiatric Disorders: From Laboratory to Clinic.- 23 • Neural Grafting for Parkinson’s and Huntington’s Disease.- 24 • Future Prospects of Gene Therapy for Treating CNS Diseases.