F. Macfarlane Burnet I have been an interested onlooker for many years at research on the biology of trace elements, particularly in its bearing on the pas­ toral and agricultural importance of copper, zinc, cobalt, and mo­ lybdenum deficiencies in the soil of various parts of Australia.  Meer

This book, covering many key aspects of autonomic nervous system maturation, was suggested by the success of a symposium on the developing autonomic nervous system held at the Spring 1982 meeting of the Federation of American Scientists for Experi­ mental Biology (Federation Proceedings 1983, 42, 1609).  Meer

Scientific investigations of a descriptive nature involve in­ creasingly refined definitions of a problem. An idea is trans­ formed after initial experiments into a working hypothesis that has a number of testable consequences.  Meer

Research into the processes of tolerance and sensitization has escalated at a substantial rate in recent years, presumably because of the fundamental importance of understanding the long-term, as opposed simply to the initial, acute effects of drugs.  Meer

A distinguished panel of internationally recognized neuroscientists comprehensively review the involvement of and changes in glial cells both during the normal aging process and in the major disorders of old age.  Meer

Since the pioneering discovery of cyclic AMP four decades ago, a multitude of signaling pathways have been uncovered in which an extracellular signal (first messenger) impacts the cell surface, thereby triggering a cascade that ultimately acts on the cell nucleus.  Meer

As the average life expectancy of many populations throughout the world increases, so to does the incidence of such age-related neurodegenerative disorders as Alzheimer's, Parkinson's, and Huntington's diseases.  Meer

Leading experts critically summarize the state of knowledge concerning the molecular, anatomical, physiological, and behavioral aspects of NPY and its congeners.  Meer

Prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases. Coverage includes novel uses of animal models of Alzheimer's, Parkinson's, and Huntington's diseases, and studies of aging.  Meer

It is now established that neuroglia are the intimate partners of neurons and that neuronal function is a result of neuron-glia interrelations at several levels of organization.  Meer

It has been established that neuroglia are involved in early neu­ ronal growth, differentiation, and migration; these issues are well discussed in the companion volume entitled Neuron-Glia Interrela­ tions During Phylogeny: I.  Meer

In Motor Activity and Movement Disorders thirteen state-of-the-art articles explicate forefront research methodologies for measuring and interpreting motor activity in animals, as well as their applications to preclinical and clinical research involving motor disorders.  Meer

Psychopharmacology may be defined as the study of the effects of drugs on behavior. As an established scientific discipline, this is a relatively new area of research.  Meer

Distinguished medical researchers from around the world review novel neural reconstructive techniques that appear to be beneficial for Parkinson's disease and hold promise for treating Huntington's disease, pain, demyelinating diseases, and stroke.  Meer

The idea for this book has evolved from our desire to present a conceptual approach to the study of neurotransmitters in epilepsy. Such an approach requires an understanding of the function of neurotransmitter systems in various experimental models of epilep­ sy.  Meer

Even before the time of organized scientific investigation, hu­ mans had begun pondering and attempting to explain the work­ ing of the brain and the mental and behavioral states it produces.  Meer

The past decade has witnessed a revolution in the attempts of scientists to under­ stand the molecular basis of dementia. Although dementia, as defined by global cogni­ tive decline involving gradual loss of memory, reasoning, judgment, and orientation, presents most commonly in the form of Alzheimer's disease (AD), an assortment of other less common disorders, such as prion and Pick's disease, can also lead to symp­ toms that are similar to those observed in patients with AD.  Meer

Neuroscience's inherent complexity and rapid growth mean that no one can keep abreast of all the changes across the field. We each bring a necessarily narrow perspective.  Meer

A distinguished international panel of authors define our current understanding of neuronal damage after ischemia and critically review the significant recent developments and progress in cerebrovascular accident (CVA) drug trials, both in animal models and in the clinical setting.  Meer