Luis Graca
The Immune Synapse as a Novel Target for Therapy
Gebonden Engels 2007 2008e druk 9783764382957Levertijd ongeveer 9 werkdagen
Gratis verzonden
Samenvatting
This volume gives an overview on the progress in immune synapse research, from basic science to clinical trials, and the major mechanisms involved. It discusses how interfering with T cell activation may lead to immune tolerance, immune modulation, and the recruitment of regulatory T cells; the role of monoclonal antibodies in tolerance induction; and mechanisms maintaining dominant tolerance.
Specificaties
ISBN13:9783764382957
Taal:Engels
Bindwijze:gebonden
Aantal pagina's:192
Uitgever:Birkhäuser Basel
Druk:2008
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Inhoudsopgave
The immune synapse and T cell activation: regulation by chemokines.- The induction of regulatory T cells by targeting the immune synapse.- Infiltrating the immunological synapse: prospects for the use of altered petide ligands for the treatment of immune pathology.- Targeting CD4 for the induction of dominant tolerance.- Anti-CD3: from T cell depletion to tolerance induction.- Immune modulation by CD40L blockade.- CTLA-4-Ig and indoleamine 2,3-dioxygenase (IDO) in dominant tolerance.- Adhesion molecules as therapeutic targets.- E3 ubiquitin ligases and immune tolerance: targeting the immune synapse from within?.- FOXP3 biochemistry will lead to novel drug approaches for vaccines and diseases that lack suppressor T cells.- TGF-ß: from its effect in T cell activation to a role in dominant tolerance.- From mice to men: the challenges of developing tolerance-inducing biological drugs for the clinic.
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