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Serie: Progress in inflammation research
gebondenEngels9783764379742
16-8-2007
This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Meer
gebondenEngels9783764382377
13-3-2009
This volume focuses on therapeutic targets that were identified after TNF blockade. All these targets have recently been registered or are currently under development for the treatment of rheumatoid arthritis. Meer
gebondenEngels9783764383336
20-10-2008
This book summarizes the most advanced technical aspects covering all steps for a thorough application of microarrays to inflammation topics – from sample generation to data analysis. Meer
gebondenEngels9783764383510
22-6-2010
Cardiomyopathy is one of the most frequent causes of heart failure. It is often associated with inadequate heart pumping or other heart function abnormalities. Meer
gebondenEngels9783764369101
27-11-2003
In recent years, the area of pharmacotherapy of GI inflammation has witnessed important progress, with new drugs and therapeutic approaches being introduced. Meer
gebondenEngels9783764369187
24-10-2003
Several new developments in the field of neuroimmunology with focus on the brain-to-immune system communication have been the incentive for this PIR volume. Meer
gebondenEngels9783764369323
24-10-2003
Heat shock proteins (HSP) have received ample interest by immunologists
over recent years. Initially they were found to be dominantly
immunogenic microbial antigens. Meer
gebondenEngels9783764369484
27-11-2003
Arachidonic acid (AA) and other 20 or 22-carbon polyunsaturated fatty acids (PUFAs) are precursors of lipid mediators of inflammation known as eicosanoids. Meer
gebondenEngels9783764370626
19-7-2005
Sodium channels confer excitability on neurons in nociceptive pathways and exhibit neuronal tissue specific and injury regulated expression. This volume provides recent insights into the control of expression, functioning and membrane trafficking of nervous system sodium channels and reviews why sodium channel sub-types are potentially important drug targets in the treatment of pain. Meer
gebondenEngels9783764370800
15-8-2005
Despite tremendous advances in the understanding of the sensory nervous system which have accompanied the recent explosive growth of the neurosciences, rema- ably few innovative medicines directed towards pain and inflammation are ava- able. Meer
gebondenEngels9783764370886
22-3-2005
Regulatory T-cells are essential components of the immune system, and several different subsets of regulatory T-cells have been described. Considerable regulatory function has been attributed to the CD4+CD25+ T-cell subset. Meer
gebondenEngels9783764358754
1-12-1998
Pain and inflammation are inextricably linked phenomena. The observation that chemical mediators with combined pro-inflammatory, algesic and/or hyperalgesic activity occur at the site of inflammation is fundamental not only to our present understanding of the inflammatory process but also to our attempts to devise clini cally useful anti-inflammatory therapies. Meer
gebondenEngels9783764358778
1-11-1998
t Heinz Red! and Gunther Sch!ag Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria The word "sepsis" derives from the Greek meaning decay or rottenness. Meer
gebondenEngels9783764359126
1-5-2000
Combinatorial chemistry in conjunction with High Throughput Screening
(HTS) is revolutionizing the drug discovery process. Yet, we have much
to learn about the integration of these powerful techniques with
information from genomics, proteomics, computation and pharmacokinetics
before dramatic increases in the drug discovery/development processes
can be achieved. Meer
gebondenEngels9783764360115
1-1-2002
Dalip J. S. Sirinathsinghii and Ray G. Hill Merck, Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK There remains a distinct medical need for new pain therapies. Meer
gebondenEngels9783764361549
1-4-2001
In the last ten years, major strides have been made in defining the
presence and role of inflammation in atherosclerosis as well as in
injury to the tissues that occurs after episodes of ischemia and
reperfusion. Meer
gebondenEngels9783764371395
20-8-2004
Since the discovery of the bone morphogenetic proteins (BMPs) more than 15 years ago, there has been an unpredicted explosion of both basic scientific discoveries and clinical reports on their use from institutions all over the world. Meer
gebondenEngels9783764372859
9-12-2005
A repertoire of 10 TLRs mediate the first response to all microbes that infect mammals. They are the long sought receptors for a wide range of microbial products. Meer
gebondenEngels9783764382957
19-10-2007
This volume gives an overview on the progress in immune synapse research, from basic science to clinical trials, and the major mechanisms involved. It discusses how interfering with T cell activation may lead to immune tolerance, immune modulation, and the recruitment of regulatory T cells; the role of monoclonal antibodies in tolerance induction; and mechanisms maintaining dominant tolerance. Meer
gebondenEngels9783764385514
15-5-2008
Completing the PIR series, this volume summarizes the major advances made in the local and systemic use of bone morphogenetic proteins (BMPs). Chapters are dedicated to the regulation of BMP-signaling pathways; biological actions of BMPs in bone, cartilage, and teeth; clinical applications; and the potential systemic use of BMPs for tissues beyond bone. Meer